Understanding wave propagation through heterogeneous materials is critical for medical imaging, material science, and acoustics. Traditional numerical methods often fail to accurately describe nonlinear wave interactions, scattering, and attenuation in complex environments such as biological tissues or layered materials. The Fullwave simulation framework integrates a mathematical model, computational methods, and software to propagate waves through heterogeneous materials. These methods are based on a previously developed numerical solution tool (referred to as “Fullwave”) that solves the full-wave equation. In addition to modeling the nonlinear propagation of waves, it describes arbitrary frequency-dependent attenuation and variations in density. This tool has previously been used to describe ultrasound image generation in the human body.  

The Advanced Datasets Graph Analysis (ADDAGRA) program provides convenient 3D visualization of large chemical datasets, permitting the analysis of relationships between chemical compounds and libraries. Chemical compounds are represented by chemical descriptors for comparison and graphing to rapidly visualize and compare large datasets. Advantages: •  Analysis and comparison of large molecular databases •  Convenient 3D graphic visualization Can be coupled with many variable selection techniques and clustering approaches

It is difficult to test a cognitive ability across development, because tasks needed to test cognitive ability evolve as the child grows. To solve this problem, UNC has designed and developed events for testing infant and toddler declarative memory that grow with the child. This product consists of 3-D printed objects and can be as simple as assembling a box and hammering a nail into the hole, or involve more complicated sequences. These tests prompt children to perform tasks in different sequences, imitate the instructor, and show a link between completing the sequence and verbal instruction. This product can be added to existing toddler developmental programs.

High Definition Cyclic Voltammetry (HDCV) Software Suite High Definition Cyclic Voltammetry (HDCV) Software Suite Advanced software suite for real-time electrochemical data acquisition and analysis Background Fast-Scan Cyclic Voltammetry (FSCV) is a critical technique for measuring neurotransmitter dynamics with high sensitivity and temporal resolution. As research questions grow more complex, traditional software platforms fail to meet the demands for enhanced flexibility, data handling, and multi-modal integration. To accommodate recent and future advances in FSCV applications, researchers at UNC have developed High Definition Cyclic Voltammetry (HDCV). Technology Overview HDCV is an electrochemical software suite that includes data acquisition and analysis programs. The data collection program delivers greater experimental flexibility and better user feedback through live displays. It supports experiments involving multiple electrodes with customized waveforms. It is compatible with transistor–transistor logic-based systems that are used for monitoring animal behavior, and it enables simultaneous recording of electrochemical and electrophysiological data. HDCV analysis streamlines data processing with superior filtering options, seamlessly manages behavioral events, and integrates chemometric processing. Furthermore, analysis is capable of handling single files collected over extended periods of time, allowing the user to consider biological events on both sub-second and multi-minute time scales. The executable file is available to license by contacting the UNC Chapel Hill team with the Connect button in the sidebar. This program requires a physical hardware key for operation. Once your request and payment is verified, a physical hardware key will mailed to you at the shipping address provided. The Connect button can also be used for inquiries about HDCV source code. Further Details: Flexible Software Platform for Fast-Scan Cyclic Voltammetry Data Acquisition and Analysis–Anal. Chem. 2013, 85, 21, 10344-10353–https://pubs.acs.org/doi/10.1021/ac402263x Benefits • Enhanced Experiment Design: Multi-electrode support with flexible waveforms and real-time visualization. • Comprehensive Data Handling: Seamless integration of electrochemical data with synchronization to behavioral events. • Advanced Analysis Tools: Offers superior digital filtering (2D-FFT), time-bin alignment, and principal component regression (PCR). • Scalable and User-Friendly: Processes long-term recordings with intuitive navigation and storage efficiency.   Offerings Add Offering    Name                   Price              Shipping   Currency   Academic user      $2,100.00        $0.00         USD  Corporate User      $4,200.00       $0.00          USD  

This virtual educational seminar series was created by clinicians from the UNC Adams School of Dentistry. The seminars are well suited to complement the local anesthesia coursework and existing texts, such as Malamed’s Handbook of Local Anesthesia, that are taught in Dental Hygiene, Dental Assisting, Dental Student, Medical Student, or Clinical Graduate Training programs. The individual seminars can be viewed alone or in combination. The seminar topics and the learning objectives for each are as follows: Seminar One: Neurophysiology of Local Anesthetic Action How sensory nerves function Relate the pharmacologic action of local anesthetic drugs to nerve function Seminar Two: Pharmacology of Local Anesthetic and Vasopressor Drugs How chemical structure of local anesthetic drugs affects clinical usage What advantages/disadvantages do vasopressor drugs added to local anesthetics offer? Seminar Three: Review of Anatomy of the Sensory Components of the Trigeminal Nerve and Associated Structures Understand the anatomic pathways for sensory nerve innervation of the maxilla and the mandible as a prelude to local anesthetic injections Anticipate the anatomic boundaries for specific local anesthetic injections Seminar Four: Equipment Essential to Drug Administration Be able to choose an appropriate method of drug ad ministration Understand the rationale underlying the design of the dental anesthesia syringe Seminar Five: Maxillary Injection Options Technique options for maxillary anesthesia and associated soft tissues Rationale for choosing among options Seminar Six: Mandibular Injection Options Technique options for mandibular anesthesia and associated soft tissues Rationale for choosing among options Seminar Seven: Complications and Side Effects of Local Anesthetic Administration Discuss rationale and prevention for the following: syncope, bleeding along injection path, drug overdosage, anesthesia of adjacent nerves, allergy, and prolonged nerve dysfunction. Seminar Eight: Special Considerations for Patients with a Compromised Health Status Understand metabolism of amide type local anesthetics relative to renal and liver disease Understand metabolism of epinephrine as it relates to cardiovascular disease and asthma Explain interactions and systemic effects between epinephrine and beta blockers, tricyclic anti-depressants, and cocaine  A preview of the seminar series can be found by downloading the preview document on the right. This preview contains links for viewing the Introduction and Seminar One videos, as well as a course outline, and learning objectives, resources, and an evaluation for Seminar One. The seminar series is available for licensing for educational use. All the material needed for implementing the seminar series in a course is provided (seminar videos, course outline, learning objectives, and seminar evaluations). The full seminar material, which contains links for streaming the seminar videos, will be available for download following acceptance of the terms of the license agreement and payment of the license fee. Offerings Name                                                                                                                                                            Price           Shipping Currency  Local Anesthesia - 21-0062 (Community Colleges)                                                                                    $500.00          $0.00     $0.00  USD   Local Anesthesia - 21-0062 (Community Colleges - Payment by Invoice. If not paying by credit card.)    $0.00              $0.00     $0.00  USD   Local Anesthesia - 21-0062 (Community Clinic)                                                                                         $200.00          $0.00     $0.00  USD  

The ductus arteriosus (DA) is a large vessel in the developing fetus that shunts blood past the pulmonary circulation in the aorta for oxygenation by the placenta. Failure of the DA to close, which is critical to sustain life after birth, is one of the more common congenital heart defects in infants. DA closure is characterized by a fall of Prostaglandin (PG) E2 levels after birth, which is essential for remodeling the DA. 15-Hydroxyprostaglandin dehydrogenase (PGDH) is the primary enzyme regulating PGE2. This mouse line was created by inactivating the gene that encodes the enzyme PGDH (HPGD), which may be useful in the clinical management of diseases where elevated PGE2 levels are beneficial. If you are an academic institution or nonprofit organization interested in this research tool for noncommercial purposes, please contact the researcher directly to inquire about availability.

5-lipoxygenase-activating protein (FLAP) is involved in the synthesis of leukotrienes.  Under certain conditions, FLAP knockout mice exhibit reduced inflammatory response, edema, response to platelet-activating factor-induced shock, and collagen-induced arthritis.  These mice can be used to investigate FLAP modulators and their effect on any of the aforementioned conditions. If you are an academic institution or nonprofit organization interested in this research tool for noncommercial purposes, please contact the researcher directly to inquire about availability.

The E4hAkita mouse provides a novel model of diabetic atherosclerosis in the absence of severe hyperlipidemia, one in which the diabetes-induced proinflammatory changes in the vasculature and the hLDLR-mediated accumulation of cholesterol in macrophages synergistically trigger foam cell lesions. No diet manipulation, such as high cholesterol, high fat, or high cholate, is necessary to induce atherosclerosis. If you are an academic institution or nonprofit organization interested in this research tool for noncommercial purposes, please contact the researcher directly to inquire about availability.

These mice possess loxP sites on either side of the Apoe gene which allows for selective, tissue-specific suppression of adipose tissue apolipoprotein E (apoE) expression and normal circulating levels. Unlike mice containing global knockout of apoE, when these mice are bred to mice that express Cre recombinase, the resulting offspring will have exon 3 deleted in only the cre-expressing tissues which can provide better insight in the function of apoE in specific tissues. A primary role of apoE is the mediation of lipid transport throughout various tissues and cells, and consequently these mice can be used in a vast range of studies including metabolism, regulation of the immune system, and neurodegenerative and cardiovascular disease. More information regarding the generation of, and studies using these mice can be found in the listed publication. These mice are available at The Jackson Laboratory, and can be found at https://www.jax.org/strain/028530. 

Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. ARID1A loss alone does not lead to tumor formation but requires concurrent activation of the phosphoinositide 3-kinase catalytic subunit, PIK3CA. If you are an academic institution or nonprofit organization interested in this research tool for noncommercial purposes, please contact the researcher directly to inquire about availability.