Building off the success of the inaugural Clinical and Environmental Health Data Workshop, this second workshop, titled “Integrating Exposures Data into Clinical Data Assets: Building a Regional Center of Excellence” will be held at RENCI from 9:00 am to 3:00 pm on Friday, February 23, 2024. This invitation-only event aims to convene participants from the first workshop and enhance the collective workshop expertise with additional regional participants with like-minded interests and expertise in order to continue the effort initiated during the first workshop on developing solutions for: developing and applying exposures models to clinical data; building the infrastructure required to create a regional, centralized, exposures data hub; and making electronic health record data more readily interoperable with environmental exposures data. After a re-introduction of the inaugural workshop and its successes, a vision for this workshop will be presented, followed by parallel breakout sessions to build on previous successes and further advance the collaborative vision of this workshop series. A complete agenda will be distributed prior to the workshop.The overall goal of the workshop series is to move toward a vision for regional leadership in clinical and environmental health research by establishing a Regional Center of Excellence, accounting for the needs of local communities and stakeholders.